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Comparison and harmonization of building wind loading codes among the Asia-Pacific Economies

Yaojun GE, Shuyang CAO, Xinyang JIN

《结构与土木工程前沿（英文）》 2013年 第7卷 第4期   页码 402-410 doi: 10.1007/s11709-013-0230-x

摘要： This paper reviews wind loading codes and standards in the Asia-Pacific Region, in particular in the 15 countries and areas. A general description of wind loading model is given as a famous wind loading chain described by four variables including velocity pressure, exposure factor, pressure coefficient, and gust response factor. Through the APEC-WW Workshops and the extensive calculations for three examples of low, medium and high rise buildings, these four important variables of wind loads are evaluated and compared with statistical parameters, mean values and coefficients of variation. The main results of the comparison show some differences among the 15 economies, and the reasons and further incorporation are discussed and suggested.

关键词： wind loading     codification     velocity pressure     exposure factor     pressure coefficient     gust response factor    

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工程因素对结构振动环境试验响应的影响

陈幼玲,朱学旺,朱长春

《中国工程科学》 2006年 第8卷 第12期   页码 62-65

摘要：

工程因素如试件装配技术状态、试验夹具、控制点位置、载荷控制等对振动试验结构响应的影响一直受到广泛的关注。分析了振动试验中几种主要的工程因素对响应的影响；分析表明，振动试验的识别结果可以预测稳定结构在使用环境下的振动响应。

关键词： 复杂结构     振动试验     结构响应     工程因素    

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Structural dimension optimization and mechanical response analysis of fabricated honeycomb plastic pavement

Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 896-908 doi: 10.1007/s11709-022-0856-7

摘要： Because of favorable mechanical properties, deformation resistance and being conducive to environmental protection, honeycomb fabricated plastic pavement slabs are highly recommended these years. At present, most studies focus on the performance of plastic materials, however, the dimension optimization of fabricated plastic pavement slab is rarely mentioned. In this paper, an optimized geometry of the honeycomb pavement slab was determined through finite element analysis. Mechanical response of honeycomb slabs with different internal dimensions and external dimensions were explored. Several dimension factors were taken into consideration including the side length, rib thickness, the thickness of both top and bottom slabs of honeycomb structure and the length, the width and the thickness of the fabricated plastic slab. The results showed that honeycomb pavement slab with 6 cm bottom slab, 12 cm top slab,18 cm side length and 6 cm rib thickness is recommended, additionally, an external dimension of 4 m × 4 m × 0.45 m is suggested. Then, the mechanical responses of this optimized fabricated plastic slab were further investigated. Significance of different influencing factors, including wheel load, elastic modulus of plastic material, base layer thickness, soil foundation modulus and base layer modulus were ranked.

关键词： honeycomb structure     plastic pavement     dimension optimization     mechanical response     factor significance    

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Evaluation of the wind energy potential of two south west sites in Nigeria

Olaleye M. AMOO

《能源前沿（英文）》 2012年 第6卷 第3期   页码 237-246 doi: 10.1007/s11708-012-0201-2

摘要： Wind resource assessment is a crucial first step in gauging the potential of a site to produce energy from wind turbines. In this paper, the wind energy potential of Abeokuta (07°03'N, 03°19'E) and Ijebu-Ode (06°47'N, 03°58'E), two south west sites in Nigeria were examined. Twenty years (1990–2010) of monthly mean wind data from a 10 m height were subjected to two-parameter Weibull analysis and other statistical analyses. The results show that the average annual mean wind speed variation for Abeokuta ranges from 2.2 to 5.0 m/s. For Ijebu-Ode, it ranges from 2.0 to 5.0 m/s. The wind power density variation based on the Weibull analysis ranges from 4.26 to 24.51 W/m for Abeokuta and from 8.54 to 76.46 W/m for Ijebu-Ode. Ijebu-Ode was found to be the better of the two sites in terms of annual variation of mean wind speed.

关键词： wind potential     wind speed     wind power density     wind gust     turbulence intensity     Nigeria    

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移动荷载作用下三塔悬索桥的强迫振动研究

冯兆祥,陈亮,缪长青

《中国工程科学》 2012年 第14卷 第5期   页码 80-84

摘要：

针对泰州大桥开展结构动力特性计算，分析了不同移动速度以及不同移动荷载大小对于三塔两跨悬索桥结构动力响应的影响。结果表明，三塔两跨悬索桥的一阶竖弯振动基频约为0.08 Hz,远低于载重汽车的固有频率，不会形成共振条件。简单的移动荷载作用下三塔两跨连续支承悬索桥的内力、位移响应与同等静力荷载作用效果比较接近。移动荷载的质量越大、速度越大，结构的内力、位移响应就越大，并与车重呈近似正比例关系。结构内力、位移的荷载放大系数不随移动荷载质量的大小而改变。

关键词： 动力特性     强迫振动     响应     荷载放大系数    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

《医学前沿（英文）》 2012年 第6卷 第4期   页码 376-380 doi: 10.1007/s11684-012-0228-0

摘要：

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

关键词： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

《结构与土木工程前沿（英文）》 2022年 第16卷 第7期   页码 871-881 doi: 10.1007/s11709-022-0863-8

摘要： The failure criteria of practical soil mass are very complex, and have significant influence on the safety factor of slope stability. The Coulomb strength criterion and the power-law failure criterion are classically simplified. Each one has limited applicability owing to the noticeable difference between calculated predictions and actual results in some cases. In the work reported here, an analysis method based on the least square support vector machine (LSSVM), a machine learning model, is purposefully provided to establish a complex nonlinear failure criterion via iteration computation based on strength test data of the soil, which is of more extensive applicability to many problems of slope stability. In particular, three evaluation indexes including coefficient of determination, mean absolute percentage error, and mean square error indicate that fitting precision of the machine learning-based failure criterion is better than those of the linear Coulomb criterion and nonlinear power-law criterion. Based on the proposed LSSVM approach to determine the failure criterion, the limit equilibrium method can be used to calculate the safety factor of three-dimensional slope stability. Analysis of results of the safety factor of two three-dimensional homogeneous slopes shows that the maximum relative errors between the proposed approach and the linear failure criterion-based method and the power-law failure criterion-based method are about 12% and 7%, respectively.

关键词： slope stability     safety factor     failure criterion     least square support vector machine    

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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

《医学前沿（英文）》 2023年 第17卷 第2期   页码 317-329 doi: 10.1007/s11684-022-0931-4

摘要： Long noncoding RNAs (lncRNAs) play a critical role in the regulation of atherosclerosis. Here, we investigated the role of the lncRNA growth arrest-specific 5 (lncR-GAS5) in atherogenesis. We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis, which presented as increased plaque size and reduced collagen content. Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells. By contrast, lncR-GAS5 knockdown promoted autophagy. Moreover, serine/arginine-rich splicing factor 10 (SRSF10) knockdown increased the LC3II/LC3I ratio and decreased the P62 level, thus enhancing the formation of autophagic vacuoles, autolysosomes, and autophagosomes. Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium, which was reversed by the knockdown of SRSF10. Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene, SRSF10. Notably, miR-193-5p overexpression decreased plaque size and increased collagen content. Altogether, these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy. In conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway. Thus, miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis.

关键词： lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

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The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 1015-1024 doi: 10.1007/s11783-014-0670-0

摘要： The Ecological Footprint (EF), a physical indicator to measure the extent of humanity’s use of natural resources, has gained much attention since it was first used by Wackernagel and Rees in 1996. In order to appraise land area types with different levels of productivity, they introduced the concept of an equivalence factor. This relates to the average primary biomass productivities of different types of land (i.e. arable land, pasture, forest, water/fishery, built-up land and fossil energy land) to the regional average primary biomass productivity of all land types in a given year. Hence, the equivalence factor is an important parameter in the EF model and it directly affects the reliability of all results. Thus, this article calculates equivalence factors on the national and provincial levels in China based on Net Primary Production (NPP) from MODIS 1 km data in 2008. Firstly, based on the Light Utility Efficiency and CASA model, the NPP of different biologically productive lands of China and of different provinces was calculated. Secondly, China’s equivalence factor for 6 land area types was calculated based on NPP: arable land and built-up land has an equivalence factor of 1.71, forest and fossil energy land has a factor of 1.41, pasture has a factor of 0.44 and water/fishery 0.35; Finally, the equivalence factor of 6 land area types in different provinces was also calculated. The NPP of each ecosystem type varies along with the equivalence factor in different provinces. However, the ranking of the equivalence factors in different provinces remain the same, with that of arable land being the largest, and the water/fishery being the smallest.

关键词： ecological footprint     equivalence factor     net primary production     biological capacity     land types    

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A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

《结构与土木工程前沿（英文）》 2021年 第15卷 第4期   页码 877-894 doi: 10.1007/s11709-021-0756-2

摘要： Many bridge design specifications consider multi-lane factors (MLFs) a critical component of the traffic load model. Measured multi-lane traffic data generally exhibit significant lane disparities in traffic loads over multiple lanes. However, these disparities are not considered in current specifications. To address this drawback, a multi-coefficient MLF model was developed based on an improved probabilistic statistical approach that considers the presence of multiple trucks. The proposed MLF model and approach were calibrated and demonstrated through an example site. The model sensitivity analysis demonstrated the significant influence of lane disparity of truck traffic volume and truck weight distribution on the MLF. Using the proposed approach, the experimental site study yielded MLFs comparable with those directly calculated using traffic load effects. The exclusion of overloaded trucks caused the proposed approach, existing design specifications, and conventional approach of ignoring lane load disparity to generate comparable MLFs, while the MLFs based on the proposed approach were the most comprehensive. The inclusion of overloaded trucks caused the conventional approach and design specifications to overestimate the MLFs significantly. Finally, the benefits of the research results to bridge practitioners were discussed.

关键词： bridges     multi-lane factor     traffic load     lane load disparity     multi-truck presence     weigh-in-motion data    

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Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

《化学科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 272-281 doi: 10.1007/s11705-009-0023-x

摘要： The effect of kinetics and shape factor on barium sulfate precipitation in a continuous stirred tank has been investigated numerically through solving the standard momentum and mass transport equations in combination with the moment equations for crystal population balance. The numerical method was validated with the literature data. The simulated results include the distribution of the local supersaturation ratio in the reactor, the mean crystal size, and the coefficient of variation. The simulation results show that the value of shape factor used in the model affected greatly the mean crystal size and the moments of the crystal size distribution. The influence of the kinetic expressions on the simulation is also analyzed. It is important to investigate the relationship of the shape factor with the precipitator type and other operation conditions to obtain reliable simulation results and suitable kinetic equations of crystal nucleation and growth rates.

关键词： stirred tank     numerical simulation     precipitation     shape factor     crystal kinetics    

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The formation mechanism and the influence factor of residual stress in machining

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 265-269 doi: 10.1007/s11465-014-0311-0

摘要：

Residual stresses generated in cutting process have important influences on workpiece performance. The paper presents a method of theoretical analysis in order to explicate the formation mechanism of residual stresses in cutting. An important conclusion is drawn that the accumulated plastic strain is the main factor which determines the nature and the magnitude of surface residual stresses in the workpiece. On the basis of the analytical model for residual stress, a series of simulations for residual stress prediction during cutting AISI 1045 steel are implemented in order to obtain the influences of cutting speed, depth of cut and tool edge radius on surface residual stress in the workpiece. And these influences are explained from the perspective of formation mechanism of residual stress in cutting. The conclusions have good applicability and can be used to guide the parameters selection in actual production.

关键词： residual stress     analytical model     strain     plastic     cutting parameter    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle cells    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 25-30 doi: 10.1007/s11684-013-0244-8

摘要：

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family. It actually functions as endocrine hormones but does not regulate cell growth and differentiation. It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolism, including enhancing insulin sensitivity, decreasing triglyceride concentrations, causing weight loss, ameliorating obesity-associated hyperglycemia and hyperlipidemia. Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth hormone axis and thermogenic function of brown adipose tissue. Clinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21 in metabolic disease remain to be determined. Both the pharmacological actions and physiological roles make FGF21 attractive drug candidates for treating metabolic disease, but some questions remain to be answered. This article concentrates on recent advances in our understanding of FGF21.

关键词： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 129-141 doi: 10.1007/s11709-007-0014-2

摘要： The assumption and problem of the mode-superposition response spectrum method in seismic design code is discussed based on a brief review of the development of the seismic design method for building structures. The scope of application for the classical damping theory is analyzed and the necessity of the research on mode-superposition method for non-classical damping is presented. The progresses on the mode superposition response spectrum theory are discussed. This includes: 1) the complex mode superposition method (in real form) for the non-classically damped linear system and the general calculation formula for the application of code; 2) the complex complete quadratic combination (CCQC) method for the non-classically damped linear system, which is based on the same assumptions as in deducing the complete quadratic combination (CQC) method which is popularly used in seismic design codes of many countries; 3) the complex complete quadratic combination with three components (CCQC3) method, which is a generalization of the CCQC method to the case of multi-components and multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic response of the non-classically damped system with overcritical damping and the calculation method of seismic response for the linear system with multiple eigenvalues; 5) the time-dependent CCQC (t) algorithm considering nonstationary earthquake ground motion; 6) an applied and effective method to solve the low order complex vector basis for the large linear non-classically damped system, which can be expediently used in practice to avoid the unknown errors coming from the forced uncoupling method; 7) bringing forward the concept of partial quadratic combination in order to reduce the calculation amount of CQC and CCQC methods, and studying the primary estimation-criterion. The reasonability and applicable scope of these methods are also briefly discussed in this paper.

关键词： generalization     classical damping     mode-superposition response     calculation formula     damping theory    

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标题 作者 时间 类型 操作

Comparison and harmonization of building wind loading codes among the Asia-Pacific Economies

Yaojun GE, Shuyang CAO, Xinyang JIN

期刊论文

工程因素对结构振动环境试验响应的影响

陈幼玲,朱学旺,朱长春

期刊论文

Structural dimension optimization and mechanical response analysis of fabricated honeycomb plastic pavement

Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI

期刊论文

Evaluation of the wind energy potential of two south west sites in Nigeria

Olaleye M. AMOO

期刊论文

移动荷载作用下三塔悬索桥的强迫振动研究

冯兆祥,陈亮,缪长青

期刊论文

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

null

期刊论文

LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes

Shiguo XIAO; Shaohong LI

期刊论文

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

期刊论文

The calculation of equivalence factor for ecological footprints in China: a methodological note

Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU

期刊论文

A practical multi-lane factor model of bridges based on multi-truck presence considering lane load disparities

期刊论文

Numerical investigation of the influence of kinetics and shape factor on barium sulfate precipitation

Zheng WANG, Zai-Sha MAO, Chao YANG, Qinghua ZHANG, Jingcai CHENG

期刊论文

The formation mechanism and the influence factor of residual stress in machining

null

期刊论文

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

期刊论文

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

null

期刊论文

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

期刊论文